2013年 首屆中國科學院王寬誠優秀女科學家獎（兩位獲獎者之一）；現任中國科學院生物物理研究所研究員，蛋白質與多肽藥物重點實驗室主任，中國生物物理學會副理事長兼秘書長。
       主持基金、項目、課題等情況
(1)傳染病檢測新技術，主持，國家級，2013-01--2015-12
(2)肝炎進展為肝癌的早期診斷標志物篩選，參與，國家級，2012-01--2015-12
(3)納米磁性顆粒生物活性研究，參與，國家級，2011-07--2015-07
(4)CD146作為關鍵節點調控非可控性炎癥惡性轉化分子機制研究，主持，國家級，2011-01--2013-12

1977–1982 河南醫科大學，醫學學士
1983–1989 中國科學院生物物理研究所，實研，助研
1989–1993 德國海德堡大學理論醫學院，博士

1994–1996 美國Memorial Sloan-Kettering癌癥研究中心，博士后
1994–至今 中國科學院微生物研究所研究員、中國科學院生物物理研究所研究員, 博導

       科研方向主要涉及腫瘤新靶點的發現和鑒定，納米探針與載體藥物在腫瘤診斷和治療的應用研究。她提出納米酶新概念（Nature Nanotechnology 2007，單篇他引1000余次），并將其應用于腫瘤診斷及治療（Nature Nanotechnoloy 2012，PNAS 2014）的系統性研究成果獲國家自然科學獎二等獎。她發表研究論文140余篇，發明專利30項，部分專利已經進入美國、歐洲和日本并實現成果轉化。

1.Gao L, Zhuang J, Nie L, Zhang JB, Zhang Y, Gu N, Wang TH, Feng J, Yang DL, Perrett S, Yan XY. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles and application in an immunoassay. Nature Nanotechnology, 2 (9) (2007), 577-83.
2.Fan KL, Cao CQ, Pan YX, Lu D, Yang DL, Feng J, Song LN, Liang MM & Yan XY. Magnetoferritin nanoparticles for targeting and visualizing tumor tissues. Nature Nanotechnology, 7(7) (2012), 459-64.
3.Minmin Liang, Kelong Fan, Meng Zhou, Demin Duan, Jiyan Zheng, Dongling Yang, Jing Feng and Xiyun Yan*. H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection. Proc Natl Acad Sci U S A. 2014;111(41) ,14900-5.
4.Zeng QQ, Li WD, Lu D, Wu ZZ, Duan HX, Luo YT, Feng J, Yang DL, Fu L and Yan XY. CD146, an epithelial-mesenchyaml transition inducer, is associated with triple-negative breast cancer. Proc. Natl. Acad. Sci. USA, 109 (4) (2012), 1127-32.
5.Zhongde Ye, Chunxia Zhang, Tao Tu, Min Sun, Dan Liu, Di Lu, Jing Feng, Dongling Yang,Feng Liu* & Xiyun Yan*. Wnt5a uses CD146 as a receptor to regulatecell motility and convergent extension. Nature Communications. 2013;4,2803.
6.Tao Tu, Chunxia Zhang, Huiwen Yan, Yongting Luo, Ruirui Kong, Pushuai Wen, Zhongde Ye, Jianan Chen, Jing Feng, Feng Liu, Jane Y. Wu*, Xiyun Yan*. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Research. 2015;25(3), 275-87.
7.Yanzhao Zhao, Minmin Liang, Xiao Li, Kelong Fan, Jie Xiao, Yanli Li, Hongcheng Shi, Fei Wang, Hak Soo Choi,* Dengfeng Cheng,* and Xiyun Yan*. Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging. ACS Nano. 2016; 10 (4), 4184–4191
8.Demin Duan, Kelong Fan, Dexi Zhang, ShuguangTan, Mifang Liang, Yang Liu, Jianlin Zhang, PanheZhang, Wei Liu, Xiangguo Qiu, Gary P. Kobinger,George Fu Gao, Xiyun Yan*. Nanozyme-strip for rapid local diagnosis of Ebola. Biosensors and Bioelectronic. 2015;74(5),134-141.
9.Yan XY, Lin Y, Yang DL, Shen Y, Yuan M, Zhang ZQ, Li PY, Xia HT, Li L, Luo DD, Liu Q, Mann K, Bader BL. A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth. Blood, 102 (1) (2003), 184-91.
10.Jiang TX, Zhuang J, Duan HX, Luo YT, Zeng QQ, Fan KL, Yan HW, Lu D, Ye ZD, Hao JF, Feng J, Yang DL, Yan XY. CD146 is a co-receptor for VEGFR-2 in tumor angiogenesis. Blood, 120 (11) (2012), 2330-9.
11.Yongting Luo,#, Hongxia Duan,#, Yining Qian,#, Liqun Feng, Zhenzhen Wu, Jing Feng, Dongling Yang, Zhihai Qin, Xiyun Yan. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Research, 2017
12.Qian Gao, Junfeng Zhang, Xiumei Wang, Ying Liu, Rongqiao He, Xingfeng Liu, Fei Wang, Jing Feng, Dongling Yang, Zhaoqing Wang, Anming Meng, and Xiyun Yan. The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nature Communications. 2017 Jun 7;8:15279.
13.Jianan Chen, Yongting Luo, Hui Hui, Tanxi Cai, Hongxin Huang, Fuquan Yang, Jing Feng, Jingjing Zhang, and Xiyun Yan. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci U S A. 2017 Sep 5; 114(36): E7622–E7631.